Gymnema sylvestre (gudmar) is a precious plant for type 2 diabetes patient . It is a natural so called in modern language OHA ( oral hypoglycemic agent ) . in local indian language gymnema is also known as madhunashini , it means a plant which basicallly destroys sugar , also known as australian cow plant . gymnema sylvestre plant basically comes from asclepediacae family .
This plant has not only good effects on type 2 diabetes but also lowers down the sugar craving , lowering cholesterol levels , antioxidant activity by scavenging the free radcials . its extract are used in dietary supplement for weight loss also .
Now , digging deeply to gymnema the phytoconstituents of the plant -:
: oleanane, gymenmic acid , gymnemasides , alkaloid , polypeptide (gurmarin) terpenoids , flavanoid , cinnaic acid , folic acid , tannin , phenol ., tartaric acid , formic acid , ascorbic acid and other derivatives also .
leaf is antidiabetic effect , stimulates the heart and circulatory system , activates the uterus , used in parageusia and furunculosis . plant – diuretic , antibilous . Root – emetic expectorant , astringent , stomachic .
Here is the game plan i.e mode of action -:
mode of action of drug is through stimulation in insulin secretion from pancreas , which basically decreases or is absent in diabetic type 2 patients . it delays the glucose absorption in blood .
Atomic arrangements of gynemic acid one of the constituents of the plant to taste buds are similar to sugar molecule which fit to the receptors in taste buds preventing the receptor activation by sugar molecule in food . similarly in intestine it attaches the receptor present in external layer of intestine thereby preventing absorption of sugar molecules . this atomic arrangment of the plant likely to taste buds is beautiful creation of god .
Hypoglycemic effect of gymnemic acid triggers insulin secretion and release , it also increase regeneration of pancreas islet cells to enhanced enzyme mediated uptake of glucose . this process decreased glucose and fatty acid assimilation in small intestine and interfers in ability of receptors in mouth and intestine to sensation of sweetness.
gymnemic acid also found to excrete faecal cholesterol , gurmar also has antiarthritic activity , helpful in dental carries , antibiotic effect , hepatoprotective effect , immunostimulatory effect , also possess wound healing activity .
the extract of dried leaves , given to diabetes rats at a dose of 20 mg /day per rat for 8 weeks , was found to bring about blood glucose homeostasis (means normal range ) by increasing serum insulin levels . increased glycoprotein level and teh resultant nephropathy , retinopathy and micro and macro angiopathy were also controlled ( referrence indian medicinal plants book ).
the leaf extract 25-100 mg/kg when orally administered to experimentally induced hyperlipidemic rats for 2 weeks , reduced the elevated serum triglyceride and total cholesterol in a dose dependent manner . the efficacy and antiatherosclerotic potential of the extract (100mg/kg) were comparable to that of a lipid powering drug or statin .
Gymnemic acid is reported to inhibit melanin formation in vitro . it also inhibit dental plaque formation .
DOSAGE – LEAF / ROOT – 3-5 GM POWDER ; 50 – 100 ML DECOCTION ( CCRAS )
Gurmar can be taken with OHA as a dietary supplement . one more thing diabetes is lifestyle disorder ayurvedic medicine are not only going to lower down the sugar levels it also rejenuvates the body with minimal side effects and work up on the the root cause like in diabetes it will give strengthening to pancreas by increasing their insulin productivity . so main thing is you have to change your life style if you are diabetic like proper diet a small diet in small interval of time + routine morning walk .
before taking gurmar consult to ayurvedic physician for dosage .
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